43 BC: Lugdunum founded at the hilly junction of the Rhône and Saône rivers. It quickly became the capital of the Gauls.
1312: Philip the Fair annexed the city to the Kingdom of France.
1450s: Lyon had spread to 36 districts, each with its own trade.
1453: Hundred Years’ War Ends. English expelled from France.
1461–83: Four annual fairs established, drawing merchants from all over Europe, especially Italy. This caused Lyon to become a major center trades including spices and silk.
1472: First printing establishment set up in Lyon. Lyon quickly became a printing center of Europe.
1476: Lyon Cathedral finished.
Late 1400s Francois I gave Lyon silk-weaving privileges, which until this point, had been reserved to Italy.
1494: Charles VIII (r. 1483–98) invades Italy in an attempt to conquer the kingdom of Naples. He succeeds, but is quickly pushed back.